Manchester City striker will miss the start of the new Premier League season after fracturing his metatarsal.
Negredo, 28, confirmed via his official Instagram account he had suffered a fracture to his fifth metatarsal, an injury that was picked up during City's pre-season friendly with Hearts.
He wrote: "I want to let you know that it's going to be hard for the next few months, I fractured my 5th metatarsal and will be out a few months. I will be back stronger than ever."
The injury looks likely to end any possibility of a summer move for Negredo, who City were considering selling in order to make way for the imminent 32 million pound arrival of Eliaquim Mangala from Porto.
With City being limited next season to 17 non-homegrown players in the Premier League and 16 in the Champions League after breaching Financial Fair Play (FFP) rules, the signing of Mangala would push them over the limits and they may be forced to offload both Negredo and Javi Garcia.
City begin a tour of the U.S. on Wednesday, where they will play Sporting Kansas, AC Milan, Liverpool and Olympiakos before facing Arsenal in the Community Shield on Aug. 10.
The Premier League champions then begin the defence of their title at Newcastle on Aug. 17.