Daniel Sturridge will miss England’s World Cup qualifier against Moldova on Friday.
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The striker has returned to Liverpool for treatment on his thigh injury but will join up with England again next week and they hope he will be fit to face Ukraine on Tuesday.
Sturridge’s withdrawal follows the loss of Wayne Rooney, who pulled out of the squad after suffering a cut to his forehead when he was hurt by Manchester United and England team-mate Phil Jones in training.
The withdrawal leaves Roy Hodgson's options up front limited, with Wayne Rooney also unavailable after suffering a severe cut to his head in Manchester United training last week. Hodgson confirmed Rickie Lambert will start against Moldova.
Sturridge has scored one goal in six games for England and has struck five times in four appearances for Liverpool this season.
But after he scored the Merseysiders’ winner against Manchester United on Sunday, manager Brendan Rodgers revealed he had been troubled by the thigh problem.
And though Sturridge linked up with England, he is yet to recover. An FA statement read: "As Roy Hodgson prepares his England team to face Moldova on Friday evening, Daniel Sturridge has returned to Liverpool for further treatment.
"The squad departed St. George's Park on Thursday afternoon ahead of the World Cup qualifier at Wembley, but the Liverpool forward will return to his club with the intention of joining the England squad again at the weekend and travelling to Ukraine."
Steven Caulker - who was called up to the squad after Glen Johnson and Phil Jones suffered injuries in Sunday's clash between Liverpool and United - will also miss out on Friday after turning his ankle in training, but like Sturridge could be back to play a part against Ukraine.