Five-time champions Brazil will open their World Cup qualifying campaign away against Copa America holders Chile.
The World Cup qualifying draws were revealed in St. Petersburg, Russia, on Saturday with the Selecao being forced to confront the freshly crowned South America champs in the opener.
Chile, coming off their first-ever continental triumph, will welcome Brazil back to the site of their most recent international failure.
Missing the services of star player Neymar, Brazil crashed out against Paraguay in the quarterfinals stage, falling in a penalty shootout for the second tournament in a row.
Neymar, who was suspended for his actions in Brazil's Copa loss to Colombia, will miss Brazil's first two qualifiers as a result of the ban.
This summer's disappointment in Chile came nearly a year after Brazil's disastrous World Cup exit on home soil, which saw them embarrassed 7-1 by Germany in the semis.
As hosts of the tournament, Brazil did not need to qualify for World Cup 2014. And the game in Chile will mark their first such match since 2009.
In addition to Brazil's trip to Chile, World Cup and Copa America runners-up Argentina will host Ecuador in the opener of their qualifying campaign.
Coming off two straight final game appearances, Argentina are still in search of their first major title since 1993.
Here's the complete list of CONMEBOL qualifying fixtures:
Round 1
Colombia vs. Peru
Chile vs. Brazil
Argentina vs. Equador
Venezuela vs. Paraguay
Bolivia vs. Uruguay
Round 2
Paraguay vs. Argentina
Brazil vs. Venezuela
Equador vs. Bolivia
Peru vs. Chile
Uruguay vs. Colombia
Round 3
Chile vs. Colombia
Argentina vs. Brazil
Equador vs. Uruguay
Bolivia vs. Venezuela
Peru vs. Paraguay
Round 4
Colombia vs. Argentina
Paraguay vs. Bolivia
Brazil vs. Peru
Venezuela vs. Equador
Uruguay vs. Chile
Round 5
Chile vs. Argentina
Brazil vs. Uruguay
Equador vs. Paraguay
Bolivia vs. Colombia
Peru vs. Venezuela
Round 6
Colombia vs. Equador
Paraguay vs. Brazil
Argentina vs. Bolivia
Venezuela vs. Chile
Uruguay vs. Peru
Round 7
Colombia vs. Venezuela
Paraguay vs. Chile
Argentina vs. Uruguay
Equador vs. Brazil
Bolivia vs. Peru
Round 8
Chile vs. Bolivia
Brazil vs. Colombia
Venezuela vs. Argentina
Peru vs. Equador
Uruguay vs. Paraguay
Round 9
Paraguay vs. Colombia
Brazil vs. Bolivia
Equador vs. Chile
Peru vs. Argentina
Uruguay vs. Venezuela
Round 10
Colombia vs. Uruguay
Chile vs. Peru
Argentina vs. Paraguay
Venezuela vs. Brazil
Bolivia vs. Equador
Round 11
Colombia vs. Chile
Paraguay vs. Peru
Brazil vs. Argentina
Venezuela vs. Bolivia
Uruguay vs. Equador
Round 12
Chile vs. Uruguay
Argentina vs. Colombia
Equador vs. Venezuela
Bolivia vs. Paraguay
Peru vs. Brazil
Round 13
Colombia vs. Bolivia
Paraguay vs. Equador
Argentina vs. Chile
Venezuela vs. Peru
Uruguay vs. Brazil
Round 14
Chile vs. Venezuela
Brazil vs. Paraguay
Equador vs. Colombia
Bolivia vs. Argentina
Peru vs. Uruguay
Round 15
Chile vs. Paraguay
Brazil vs. Equador
Venezuela vs. Colombia
Peru vs. Bolivia
Uruguay vs. Argentina
Round 16
Colombia vs. Brazil
Paraguay vs. Uruguay
Argentina vs. Venezuela
Equador vs. Peru
Bolivia vs. Chile
Round 17
Colombia vs. Paraguay
Chile vs. Equador
Argentina vs. Peru
Venezuela vs. Uruguay
Bolivia vs. Brazil
Round 18
Paraguay vs. Venezuela
Brazil vs. Chile
Equador vs. Argentina
Peru vs. Colombia
Uruguay vs. Bolivia