Liverpool managed a 1-1 draw at Manchester United to advance to the quarterfinals of the Europa League 3-1 on aggregate on Thursday.
Philippe Coutinho supplied an away goal after Anthony Martial's opening penalty to see the visitors through at Old Trafford.
Jesse Lingard had a chance to open the scoring with an unmarked header in the 19th minute but sent it straight at Simon Mignolet, who made a fine reaction save.
United's breakthrough came in the 35th minute as Nathaniel Clyne tripped up Martial in the box, and the Frenchman sent Mignolet the wrong way from the penalty spot.
In response, Liverpool went on the attack, with Daniel Sturridge banging a free kick off the crossbar and Jordan Henderson sending a shot over from the centre of the box.
The away goal came in the 45th minute, when Coutinho raced past Guillermo Varela on the wing and chipped David De Gea from close range.
That meant United needed three goals in the second half to go through, but they could not find any as they crashed out.
Pierre-Emerick Aubameyang scored twice as Borussia Dortmund reached the quarterfinals of the Europa League with a 2-1 win at indifferent Tottenham.
Spurs boss Mauricio Pochettino has already said he'd rather concentrate on their Premier League title race and again played a conservative lineup with Harry Kane on the bench.
And any hope Tottenham had of overturning their 3-0 first-leg defeat in Germany ended when Aubameyang curled in a stunning strike from distance in the 24th minute.
Aubameyang scored his second in the 71st minute, beating Hugo Lloris from the right side, and though Spurs got a goal back three minutes later through Son Heung-min, that was all for their comeback.
Sparta Prague pulled off a stunning scoreline at Lazio on Thursday, winning 3-0 to advance to the Europa League quarterfinals 4-1 on aggregate.
The Czech side took the lead on 10 minutes when Borek Dockal fired home with his first touch from the top of the box.
And less than two minutes later, Sparta's Ladislav Krejci placed a low shot inside the far post.
And it got worse for the Serie A side before half-time when Lukas Julis made it 3-0 by redirecting a cross on the volley past Lazio keeper Federico Marchetti.
Aritz Aduriz's 75th-minute goal saved Athletic Bilbao, who advanced on away goals despite a 2-1 defeat at Valencia.
Valencia had overturned a 1-0 deficit from the first leg but could not hold on and crashed out with the tie 2-2 on aggregate.
Santi Mina opened the scoring for the hosts in the 12th minute when Athletic keeper Iago Herrerin could only parry an Alvaro Negredo shot into the path of the striker.
Aderlan Santos made it 2-0 in the 37th minute by heading in Jose Gaya's cross at the far post.
But Aduriz scored his eighth Europa League goal of the season to flip the script and put Athletic through. Valencia boss Gary Neville thought the play had started with a hand ball and was sent to the stands for protesting the decision.
Kevin Gameiro scored twice in two minutes just before half-time and holders Sevilla put away Basel with a 3-0 win at home.
Following a goalless first leg, Adil Rami provided the breakthrough in the 35th minute when he stooped low to redirect a header into the net off the inside of the far post.
Gameiro bundled home his first goal on 44 minutes after Basel failed to clear, and moments later he had a second after his header hit the bar and bounced back at him to tap in.
Braga rallied to beat Fenerbahche 4-1, defeating their Turkish opponents 4-2 on aggregate.
The Portuguese side took the lead on 19 minutes when Ahmed Hassan was played through on goal and perfectly placed the ball inside the far post with his first touch.
But Alper Potuk put Fenerbahce back in front with a crucial away goal on the stroke of half-time. Robin van Persie's header was blocked and fell to Potuk to lash home.
But Mehmet Topal was given his second yellow card for an inadvertent hand ball in the box, and Josue converted the penalty.
Fener still led on away goals at that point, but Nikola Stojiljkovic found Braga's winner five minutes later by fighting off a stiff challenge to retain his balance and score, before Rafa Silva kicked off celebrations with a late fourth.
Alper Potuk and Volkan Sen were both sent off late as frustrated Fenerbahce finished with eight men.
Villarreal kept Javier Hernandez and Bayer Leverkusen off the scoresheet and advanced with a goalless draw.
The Spanish club held a 2-0 advantage from their home leg and Sergio Asenjo kept a clean sheet in Germany.
Shakhtar Donetsk are also through to the quarterfinals thanks to a 1-0 win at Anderlecht.
Oleksandr Kucher was sent off for Shakhtar six minutes from time, but Kara Mbodji's red card three minuets later for the hosts ensured the game ended 10 versus 10.
A draw would have been enough to put Shakhtar through, but Eduardo scored with the last kick of the game to seal matters.