Huddlestone has not featured for Spurs since the 5-1 loss to Manchester City on August 28 and Redknapp said he will go under the knife on Monday.
Redknapp said: "He needs another operation. He's already had one but there is still a problem with him. It's a blow. He will be out for a while."
Huddlestone later tweeted: "Thanks for the supportive msgs, I will do everything I can to be fully fit asap. Once the op is complete I will have a better idea of time. Didn't think an operation would get my name trending lol, thanks again for the tweets!"
Tottenham have also announced that defender William Gallas has suffered another calf injury, but Michael Dawson is making good progress after an Achilles problem and Aaron Lennon and Danny Rose are available again. Steven Pienaar could also feature against Shamrock Rovers in Thursday's Europa League tie.
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