Vicente Del Bosque has named three new faces in his Spain squad for the friendly against Chile and the Euro 2012 qualifier with Liechtenstein.
Atletico Madrid centre-half Alvaro Dominguez, Sporting Gijon defender Alberto Botia and Barcelona B man Martin Montoya were all called up.
Del Bosque argued it was a natural progression for players who starred in Spain's recent European Under-21 Championship triumph to move into senior contention.
He said: "There are a few new names on the squad list but this does not mean we are eliminating anyone from future call-ups, such as (Carlos) Marchena and (Joan) Capdevila.
"We have taken this opportunity to bring in some youngsters, six kids who were champions of the Under-21 Euros. We will be able to learn more about them.''
Spain meet Chile in Geneva on September 2 before taking on Liechtenstein in a Euro 2012 qualifier four days later.
Spain squad: Iker Casillas (Real Madrid), Jose Reina (Liverpool), Victor Valdes (Barcelona); Alvaro Arbeloa, Raul Albiol, Sergio Ramos (all Real Madrid), Alberto Botia (Sporting Gijon), Alvaro Dominguez (Atletico Madrid), Martin Montoya (Barcelona); Xabi Alonso (Real Madrid), Sergio Busquets (Barcelona), Santiago Cazorla (Malaga), Andres Iniesta, Thiago Alcantara, Xavi, Cesc Fabregas (all Barcelona), Javi Martinez (Athletic Bilbao); David Villa & Pedro (Barcelona), David Silva (Manchester City), Fernando Llorente (Athletic Bilbao), Fernando Torres (Chelsea), Alvaro Negredo (Sevilla), Juan Mata (Chelsea).