AC Milan extended their lead at the top of Serie A and pushed Sampdoria closer to relegation with a comfortable 3-0 win at the San Siro as city-rivals Inter slipped to defeat at Parma.
Clarence Seedorf put the home side in front after 20 minutes and Antonio Cassano doubled their lead from the penalty spot 10 minutes into the second half.
Robinho wrapped up the win for the Rossoneri six minutes later to move them six points clear of Napoli, who host Udinese on Sunday. Sampdoria face the prospect of slipping into the bottom three on Sunday.
Inter Milan's hopes of winning a trophy this season may well depend on their Coppa Italia tie with Roma on Tuesday after a 2-0 defeat at Parma saw them fall further off the pace in the race for the Scudetto.
Goals from Sebastian Giovinco in the first half and Amauri after the break inflicted a second defeat in three days on the Nerazzurri, who followed up their Champions League elimination to Schalke with a defeat which leaves them eight points adrift of Serie A leaders AC Milan with five games remaining.
Parma, on the other hand, move four points clear of the bottom three thanks to a crucial win at the Stadio Tardini.
Abel Hernandez struck twice in the last six minutes as Palermo ruined a big day for Roma with a 3-2 defeat after the sale of the Eternal City club to foreign investors.
The kick-off at the Stadio Olimpico came just 16 hours after Thomas DiBenedetto led an American consortium in buying the majority holding in the Giallorossi - the first time in Serie A history that a major club had fallen into foreign hands.
And the hosts started well on the pitch with captain Francesco Totti putting them in front in the 20th minute from the penalty spot.
Mauricio Pinilla levelled with a penalty before half-time and after the Romans missed a hatful of chances in the second half, Hernandez made them pay with two goals.
Substitute Mirko Vucinic reduced the arrears with seconds remaining but Roma endured a setback that has further damaged their chances of a top-four finish.