Lyon president Jean Michel Aulas believes Jose Mourinho will tell Real Madrid to target a goalless draw when the teams meet at the Bernabeu on Wednesday.
Madrid have a potentially crucial away goal going into the second leg after securing a 1-1 draw at the Stade Gerland, and a 0-0 draw would be enough to take the Spanish giants beyond the second round for the first time since 2004.
Lyon managed to progress with a 2-1 aggregate victory over Madrid at this stage last season having won 1-0 at home, but Aulas knows they will be fighting an uphill battle this time around after drawing the first leg.
"I am sure Mourinho will play for a 0-0, but we will try to qualify and if we do it will be an unprecedented feat," he told the official Lyon website. "The conditions are not the same as last year, and it will be even harder to go through having drawn at home. We are not afraid of anyone."
However, former Lyon striker Karim Benzema, who scored Madrid's away goal in the first leg, believes his team-mates need to go on the attack if they are to progress.
"We know that, when it comes to the Champions League, every team finds a higher level," he told AS. "That is what you would expect. Lyon are a very solid team.
"They know they have to attack as they have to score a goal as Madrid carry a slight advantage from the first leg, but I know them very well and I'm aware that their positioning is very good.
"They won't leave many gaps - they can attack without neglecting their defensive responsibilities, so we have to go for the win from the second the whistle goes."