Marcus Berg and Balazs Dzsudzsak both scored twice as Eredivisie leaders PSV Eindhoven won 4-0 away to AZ Alkmaar.
Berg opened the scoring after eight minutes and Dzsudzsak added a second on the half hour. With 66 minutes gone Dzsudzsak added his second before Berg completed the scoring with 13 minutes to go.
The emphatic win extended PSV's goal difference advantage to 16 over FC Twente who also picked up three points.
Nancer Chadli scored the only goal of the game as FC Twente kept up the pressure at the top of the table with a 1-0 victory over Vitesse Arnhem.
Feyenoord moved another step closer towards certain Eredivisie safety with a 2-1 victory over Heracles Almelo. Ryo Miyaichi, the teenage Japanese forward on loan from Arsenal, and Diego Biseswar found the target for the Rotterdam side, with Mark-Jan Fledderus on the scoresheet for Heracles.
In-form ADO Den Haag remained on course for European football and kept VVV-Venlo mired in the drop zone with a convincing 3-0 victory over their struggling opponents.
Jens Toornstra opened the scoring for ADO seven minutes into the second half and Dmitri Bulykin doubled their advantage from the penalty spot 11 minutes later before sealing the triumph seven minutes from time.
Dries Mertens scored twice and Ismo Vorstermans netted a late equaliser as FC Utrecht earned a 3-3 draw away to Willem II.
The visitors led through Mertens but Jan-Arie van der Heijden levelled up for the home side. Juha Hakola put the home side ahead before half-time and then Mertens netted his second 10 minutes into the second half.
The game looked to be heading for a 2-2 draw but Maceo Rigters scored with a minute to go - only for Vorstermans to grab an even later goal to ensure the points were shared.