Ryan Giggs scored a first-minute penalty as Manchester United knocked rivals Liverpool out of the FA Cup with a 1-0 victory at Old Trafford.
With Kenny Dalglish returning to Anfield to replace the departed Roy Hodgson, his side were soon on the backfoot after Daniel Agger was deemed to have brought down Dimitar Berbatov in the opening minute.
Giggs made no mistake from the penalty spot as United took an early lead. And Dalglish's day went from bad to worse when skipper Steven Gerrard was shown red for a two-footed lunge on Michael Carrick ten minutes before half-time.
With Liverpool down to ten men, United enjoyed much of the possession and the best of the chances, with Javier Hernandez coming close shortly after half-time. Berbatov held up the ball on the edge of the area, laid off to Darren Fletcher, whose cross found Hernandez, but the Mexican's header snuck just wide of the post.
Liverpool had a handful of half-chances, including Fernando Torres' effort; a well-struck shot blocked by Rio Ferdinand.
Reina was quick off his line to smother a Berbatov effort after Patrice Evra deflected the ball into the path of the Bulgarian. And the Reds keeper continued to keep his side in the tie, making a string of instinctive saves as the ball ping-ponged around in the Liverpool penalty area.
United continued to search for a second goal to kill the game off, while Liverpool's chances were few and far between, but Giggs' early penalty proved to be the difference between the two sides. United now travel to Southampton for the third time in seven seasons.
Sven Goran-Eriksson landed a blow on his old club as Leicester drew 2-2 with Manchester City at the Walkers Stadium. The Swede, who left City in 2008, saw his side get off to a flying start when Sol Bamba netted his first goal in English football on his City debut after getting on the end of Paul Gallagher's cross.
City responded well to that early setback, however, and drew level when James Milner took advantage of some ponderous defending to drill a left-footed shot home from 18 yards. He then turned provider just before half-time, firing in a low cross that Carlos Tevez deflected into the net with an ingenious flick.
The visitors appeared to be cruising after an hour, controlling possession and taking the sting out of their opponents, but a dreadful mistake from Joe Hart, who dropped the ball at the feed of Andy King after failing to deal with Gallagher's cross, saw Leicester equalise.
And they could have been ahead when Bamba soared highest to meet Gallagher's cross - but Milner nodded off the line. Although City had their chances late on - Chris Weale produced a fine save to deny Nigel de Jong - the draw was a fair result, and the sides will meet again for the chance to face Notts County in the Fourth Round.
Chelsea put their league woes behind them with a 7-0 thrashing of managerless Championship side Ipswich Town. With both sides enduring a poor run of form in their respective leagues, the Premier League side showed their class with a dominant victory at Stamford Bridge.
It took over half-an-hour for the holders to find a way through, but two goals in the space of 60 seconds all but ended the tie. Salomon Kalou opened the scoring, slamming home from close range after Marton Fulop failed to deal with Nicolas Anelka's fierce strike.
Daniel Sturridge doubled Chelsea's lead from the restart, backheeling into the Ipswich net, before Carlos Edwards deflected the ball into his own net from Frank Lampard's free-kick as Chelsea took a 3-0 lead into half-time.
Anelka scored his first and Chelsea's fourth shortly after the break, and Sturridge added another goal to his account. Frank Lampard scored two in two minutes to seal the rout, and progress into the Fourth Round, where they will meet Everton.
Jermain Defoe struck twice to sink his old club as Tottenham avoided an FA Cup upset with a 3-0 win at home to Charlton. Andros Townsend scored on his debut to put Spurs ahead shortly after half-time with a well-struck strike from 20 yards.
Defoe sealed the victory with a superb individual goal at White Hart Lane, jinking past two defenders before slotting the ball past Rob Elliot. And he followed up with a rebound to put the result beyond the League One side.