Mourinho, Sergio Ramos and Xabi Alonso are facing UEFA action over claims that the Portuguese chief told his players to get themselves deliberately sent off against Ajax in order to have their yellow card count wiped clean ahead of the Champions League knockout stages.
Wenger expressed his disappointment when asked about the midweek incident, saying: "It's a pity to see that from a big club. It looks, frankly, horrible. You don't want to accept that."
But Mourinho, who courted controversy in 2005 when he described Wenger as a "voyeur", has told the Frenchman to keep his mouth shut and concentrate on his own side's misgivings - following the Gunners defeat to Braga.
"He should especially explain to Arsenal supporters how he can't win one single little trophy since 2005," Mourinho was quoted as saying in The Sun. "Instead of speaking about Real Madrid, Mr Wenger should speak about Arsenal and explain how he lost 2-0 against a team in the Champions League for the first time."
The 'Special One' then stepped up his attack on Wenger, urging him to stop making excuses about his side's inexperience.
"The history about the young kids is getting old now," Mourinho added "Sagna, Clichy, Walcott, Fabregas, Song, Nasri, Van Persie, Arshavin are NOT kids. They are all top players."
Mourinho and Wenger had a number of clashes during the Portuguese's three-year tenure at Chelsea, the most notable of which was the "voyeur" jibe, when he accused the Frenchman of being obsessed with the Blues.
"I think he is one of these people who is a voyeur," Mourinho said in October 2005. "He likes to watch other people.There are some guys who, when they are at home, have a big telescope to see what happens in other families. He speaks, speaks, speaks about Chelsea."