Italian champions Inter Milan fell to a shock 2-1 defeat to Chievo, as the pressure on new boss Rafael Benitez mounts.
Without the likes of Diego Milito, Walter Samuel, Thiago Motta, Maicon, Julio Cesar and Coutinho for this match, Inter now drop to sixth and are nine points off leaders and city rivals AC Milan. They may also be without striker Samuel Eto'o, who escaped punishment for a chest headbutt on Chievo centre-back Cesar (in a similar fashion to Zinedine Zidane at the 2006 World Cup), as he will surely be given a ban by the Itailan FA.
Sergio Pellissier opened the scoring as he rose high to head home Nicolas Frey's cross and Chievo doubled their lead eight minutes from time as substitute Davide Moscardelli stabbed home from close range.
Eto'o scored a brilliant consolation goal deep into injury time after a fantastic dribble, but reports suggest that boss Benitez may not see the end of his striker's expected ban if the club get anything other than a win against FC Twente in the Champions League on Wednesday.
Juventus moved up to third in Serie A thanks to a 2-0 win at Genoa on Sunday.
An Eduardo own goal and a Milos Krasic strike decided the game in the first half to take the Bianconeri above Napoli and Roma and behind AC Milan and Lazio in the standings. The defeat was the first for Davide Ballardini since he took over as coach of Genoa just over almost three weeks ago.
Two goals in the space of five minutes earned Juventus this valuable away win. The first came in the 18th minute when Claudio Marchisio's shot took a deflection off Dario Dainelli. Genoa's goalkeeper Eduardo tried to get across to make the save but he was unfortunate as the ball came back off the post and hit him to rebound across the line.
Krasic then doubled the Bianconeri's lead in the 23rd minute as the Serbia winger cut in from the right past Domenico Criscito and shot towards the far corner. Again, Portuguese stopper Eduardo got a hand to it, but he only touched the ball on its way into the far corner.
Two goals from Marek Hamsik guided Napoli to an emphatic 4-1 victory against Bologna to move up to third. Christian Maggio opened the scoring after just three minutes before Hamsik struck twice as the hosts took a three-goal lead.
Riccardo Meggiorini pulled one back but Edison Cavani restored the three-goal cushion and joined Samuel Eto'o as the league's leading scorer.
Lazio lost ground on the Serie A leaders after being held to a 1-1 draw at Parma.
Former Lazio striker Hernan Crespo scored midway through the first half but an own goal from Luca Antonelli before the break brought the Roman club back on level terms. Both teams had several chances to grab a second goal in the second half but failed to do so.
Sampdoria edged an unlikely 3-2 classic as Giampaolo Pazzini provided the goal touch they have been missing with a hat-trick to end Lecce's unbeaten start to the season at Stadio Via del Mare.
Pazzini fired Samp into a two-goal lead by the 39th minute but the Giallorossi came storming back in the second period with goals from David Di Michele (72) and Souleymane Diamoutene (83). It seemed set to end all square but the visitors left with all three points thanks to Pazzini's decider in the 88th minute.
Cagliari climbed away from the relegation zone with a 2-1 win over fellow strugglers Brescia.
The visitors began the day outside the bottom three on goal difference only, with both sides on 11 points from 12 games. But they recovered from going a goal down early on to score twice in three second-half minutes to claim a vital win, their first away from home this season.
Christian Terlizzi's late goal gave 10-man Catania a 1-0 victory at home to bottom side Bari. Beaten 3-1 in last weekend's Sicilian derby by Palermo, Catania bounced back to maintain their unbeaten run at the Angelo Massimino stadium this season.
Catania had Maxi Lopez sent off after he picked up his second yellow card 12 minutes from the end, but Bari failed to take advantage of their numerical superiority.
Cesena remain in trouble at the foot of the Serie A table after falling to a 2-1 home defeat against Palermo.
Fabrizio Miccoli's goal six minutes after the interval proved to be the telling blow, after Erjon Bogdani had cancelled out Josip Ilicic's opener for the visitors.