PSV Eindhoven edged ahead of Ajax at the top of the Eredivisie on goals scored after seeing off NEC Nijmegen 3-1.
PSV trailed at the break to John Goosens' 37th-minute strike - 10 minutes after his introduction as a substitute - but second-half strikes from Danny Koevermans, himself a replacement, Ibrahim Afellay and Ola Toivonen turned the game in the hosts' favour.
The two were locked at the summit prior to Saturday's action but although PSV's victory was matched - in points terms at least - by the Ajax, who beat rock-bottom Willem II 2-0, Fred Rutten's men now hold the slenderest of advantages.
Two penalties from the prolific Luis Suarez gave Ajax the win at the ArenA. The Uruguayan opened the scoring after 33 minutes and his second spot-kick eight minutes into the second half settled matters.
Defending champions FC Twente stay third after winning 2-1 at VVV-Venlo. Bryan Ruiz gave the visitors a 29th-minute lead and although Patrick Paauwe levelled from the spot three minutes before half-time, Roberto Rosales grabbed the winner with 20 minutes to go.
Roda JC moved up to fourth with a 2-1 victory at AZ Alkmaar. Willem Janssen grabbed the winner after Rasmus Elm had cancelled out Laurent Delorge's opener.
Excelsior's strong start continued as second-half goals from Roland Bergkamp and Leendert van Steensel saw them come from behind to beat Heracles, who had led through Mark-Jan Fledderus' 36th-minute opener.
Two goals in the final three minutes handed Heerenveen a dramatic win against Vitesse Arnhem. Davy Propper's 76th-minute effort appeared to have handed struggling Vitesse just their second win of the season but Roy Beerens equalised with an 88th-minute penalty before Oussama Assaidi struck a last-gasp winner.