Three second-half goals helped Fluminense extend their lead at the top of Brazil's Campeonato to six points with victory at Goias.
After a goalless first half Stecanela Washington broke the deadlock in the 64th minute and further strikes from Marcio Emerson and substitute Marco Antonio Marquinho sealed the win.
Second-placed Corinthians lost ground as they fell to a 1-0 defeat at Cruzeiro, Walter Montillo grabbing the only goal after just two minutes.
But third-placed Botafogo were winners as Pereira de Oliveira's strike gave them a 1-0 home win over Ceara while Internacional beat Avai by the same scoreline despite having Wilson Tiago Mathias dismissed in the second half, Marcos Indio getting the goal.
Ten-man Santos came from a goal down to win 2-1 at Gremio. Humberlinto Borges had put the hosts ahead in the fifth minute before recent Chelsea target Neymar levelled from the spot after 69 minutes.
The visitors then had Alex Sandro sent off but Rodriguinho secured all three points in stoppage time. Atletico Paranaense beat Gremio Prudente 1-0 while Sao Paulo and Vasco de Gama played out a goalless draw.