After selling David Villa to Barcelona on Wednesday, reports in Spain claim Valencia are also poised to lose David Silva to Real Madrid in the coming days.
Villa and Silva stayed at the club last summer despite Valencia's financial difficulties but Los Che will be deprived of their two finest players if Real, as reported, do sign Silva in the next week.
Silva has also attracted interest from Manchester United but Marca reports that he could become a Real Madrid player before flying out to South Africa to represent Spain at the World Cup finals.
Following the completion of the £34.2 million deal that took Villa to Barcelona, Valencia president Manuel Llorente said on Wednesday: "I do not discount further exits."
Valencia look to be busily preparing for next season and announced on Thursday that they have reached an agreement to sign Grenoble star Sofiane Feghouli.
The 20-year-old, who plays as an attacking midfielder, has agreed a four-year contract and joins Turkey midfielder Mehmet Topal and Portugal defender Ricardo Costa is signing for the club this week.