Carlo Ancelotti's Chelsea won the Premier League title in style on the final day of the season, beating Wigan Athletic 8-0 at Stamford Bridge to set a new record of 103 goals scored in a single league campaign.
Dethroned champions Manchester United beat Stoke City 4-0 at Old Trafford but needed the Blues to drop points at home and despite signing off with a win Sir Alex Ferguson's side missed out on an unprecedented fourth consecutive championship.
Chelsea striker Didier Drogba bagged a hat-trick to take his personal goal-tally to 29 to scoop the Premier League Golden Boot award ahead of United's Wayne Rooney, on 26.
The Blues have scored seven goals or more on four occasions this season and Nicolas Anelka began the deluge on Sunday after just six minutes. Frank Lampard then netted from the penalty spot as Gary Caldwell was sent off for a foul on the midfielder in the box.
Against ten men, Chelsea cruised to victory with Anelka and Salomon Kalou scoring after the break, before Drogba hit his triple and Ashley Cole completed the rout.
At Old Trafford, England striker Wayne Rooney sparked a World Cup scare when he limped off in the 77th minute, having appeared to suffer a recurrence of the groin problem he first sustained at Blackburn last month.
It had no effect on the outcome though, as Darren Fletcher and Ryan Giggs scored before the break and a Danny Higginbotham own goal and Park Ji-sung's diving header doubled their advantage at the end.
Arsenal finished third after beating a much-changed Fulham side, who had one eye on the Europa League final, 4-0 at Emirates Stadium.
Andrey Arshavin capitalised on a mistake from goalkeeper Mark Schwarzer before Robin van Persie fired in a second, with Chris Baird bundling in an own goal. Fulham, who face Atletico Madrid in Hamburg on Wednesday, made eight changes, and substitute Carlos Vela rounded off a comfortable win with four minutes left.
Liverpool's dismal season ended as it began with a whimper as they were second best in a 0-0 draw at relegated Hull City. If this was to be Rafael Benitez's last match in charge - and his future remains very much in doubt - it would be a sad end to his Anfield reign.
Hull had the better chances with Mark Cullen missing two close-range efforts in the first half, while the closest Liverpool came was when Alberto Aquilani hit the crossbar just before the interval.
Relegated Burnley went down fighting as they battled back from two down to defeat Tottenham Hotspur 4-2 at Turf Moor, courtesy of a superb second-half display.
Spurs secured their spot in the Champions League with victory over Manchester City on Wednesday and they looked to be cruising when Gareth Bale and Luka Modric netted inside 32 minutes.
But Wade Elliott pulled one back before the break and incessant Burnley pressure in the second half paid off when first Jack Cork levelled and then Martin Paterson put the Clarets ahead. Steven Thompson put the icing on the cake with a late fourth.
Shaun Wright-Phillips and Adam Johnson pressed their World Cup claims by combining to earn Manchester City a point with a 1-1 draw against West Ham.
England assistant coaches Franco Baldini and Ray Clemence were in the stands to run their eye over six potential summer stars ahead of Tuesday's 30-man provisional squad announcement.
Wright-Phillips' far-post header from Johnson's cross drew City level after Luis Boa Morte had put West Ham ahead on his return to the side after a year on the treatment table.
Adlene Guedioura slammed home his first Wolves goal as Mick McCarthy's men beat nine-man Sunderland 2-1 at Molineux Stadium.
Guedioura converted Ronald Zubar's cross with 12 minutes to go to wrap up the points after Kevin Doyle's 10th minute penalty had cancelled out Kenwyne Jones' opener for the visitors.
Goals from Kevin Davies and Ivan Klasnic gave Bolton Wanderers some home comfort against Birmingham City with a 2-1 win at the Reebok Stadium.
Davies made the breakthrough in the 33rd minute when he headed home a free-kick from Paul Robinson. Klasnic extended their lead, only for James McFadden to pull a goal back for Birmingham after Chris Benitez's penalty had been saved by Jussi Jaaskelainen.
Blackburn Rovers finished their campaign with a 1-0 victory at Aston Villa courtesy of Richard Dunne's late own goal. Dunne headed into his own net six minutes from time to ensure Rovers finished 10th and Villa 6th.
Everton's Russian substitute Diniyar Bilyaletdinov fired a superb injury-time winner to send already-relegated Portsmouth out of the Premier League with a 1-0 defeat.