Eredivisie: McClaren's Twente claim first ever title
Bryan Ruiz and on-loan Chelsea midfielder Miroslav Stoch were the men on target in either half - the opener arriving just seconds after NAC midfielder Csaba Feher had been sent off.
NAC never looked like causing the upset second placed Ajax required to leapfrog Twente at the summit - particularly after Feher's dismissal. The Hungarian saw red for a two-footed lunge on Theo Janssen after 22 minutes, and moments later Ruiz put Twente a goal up. Stoch gave the Enschede outfit some breathing space with a second goal 16 minutes from time.
The outcome secured Twente a first title since the club was formed in 1965 by the merger of Sportclub Enschede and Enschedese Boys and ensured former England manager McClaren, who took up the reins in summer 2008, went one better after guiding the club to second place in his first season at the helm.
The result ensured McClaren's side finished one point clear of Martin Jol's Ajax, who were 4-1 winners at NEC Nijmegen. Jol's side finished the campaign with a goal difference of +86 (46 better than Twente's) but had to settle for second place and a Champions League qualifying berth.
Luis Suarez started and finished the scoring for Ajax in their rout of NEC, with Demy De Zeeuw and Marko Pantelic also notching in the first half. But the Amsterdammers' destiny was out of their own hands and McClaren took the plaudits.
Retiring striker Roy Makaay struck a hat-trick on his home farewell as Feyenoord thumped Heerenveen 6-2. Makaay, a former Holland international, last month announced he would hang up his boots at the end of the season and signed off in style as Feyenoord snatched a fourth-placed finish in the Eredivisie - their highest in four seasons.
AZ Alkmaar completed a disappointing season by slipping to fifth on the back of a 1-1 draw at home to third-placed PSV Eindhoven.
Mounir El Hamdaoui grabbed the point for the Alkmaar side with an equaliser 20 minutes from time after Otman Bakkal had made the breakthrough for PSV nine minutes earlier.
Roda JC snuck into the Europa League play-offs as Davy de Fauw struck two minutes from time to spare their blushes with a 3-2 win against relegation-threatened Willem II. Roda had seemed on course for a comfortable victory thanks to Boldiszar Bodor's 34th-minute strike and Mads Junker's penalty five minutes after the break, but the visitors fought back through Marlon Pereira (69) and Said Boutahar (75).
Roda JC will be joined in the Europa League play-offs by Heracles Almelo, FC Utrecht and FC Groningen.
Heracles were 4-2 winners over ten-man ADO Den Haag. Marko Vejinovic, Everton and Birger Maertens put them in control and Darl Douglas sealed matters after Timothy Derijck and an Antoine van der Linden own goal had given ADO hope.
The visitors' cause was not helped by the 57th-minute dismissal of Karim Soltani.
Utrecht relinquished a two-goal lead to draw 2-2 at home to Vitesse Arnhem. Dries Mertens and Jacob Mulenga had the hosts two up within the hour but Onur Kaya and Santi Kolk notched in the final half-hour to nick a point for 14th-placed Vitesse.
Groningen enjoyed a comfortable final afternoon with a 3-1 home win over Sparta Rotterdam, who were already consigned to a relegation play-off place.
Koen van de Laak, Tim Matavz and Fredrik Stenman had Groningen in command before Joshua John's late consolation.
Finally, in a game with little but pride at stake, bottom club RKC Waalwijk concluded their miserable campaign with a 2-1 home loss to VVV Venlo.
The hosts had looked on course for only a sixth league win of the season when Hans Mulder put them ahead five minutes after the interval, but second-half strikes from Sandro Calabro and substitute Ruud Boymans put paid to those thoughts.