PSV Eindhoven have parted company with striker Jonathan Reis after claiming the Brazilian tested positive for a banned substance and refused to seek professional help.
According to the club's official website, the 20-year-old returned five days late following a holiday in Brazil and, because of his poor physical condition, was sent to hospital for examination.
These tests, say the club, revealed use of a banned substance and, when Reis refused professional help, PSV felt they had no option but to release the player.
PSV general manager Jan Reker said: "This is a tough but inevitable decision. We have discussed the situation of Jonathan Reis at great length and we came to the conclusion that PSV has no other choice.
"The club and head coach Fred Rutten in particular have done their very best to help Reis, but all to no avail."
Renato Moura, the player's agent, described the situation as "a nightmare".
"I must admit I am very disappointed and sad that such a gifted player of one of the best clubs in the world, should be throwing his career away," Moura said in a statement published on PSV's website.
"It is incredible that Jonathan, who has received so much help from the club, should give up his football career so light-heartedly. This is a nightmare for everyone.
"PSV and I have done our utmost to help him, so it's extremely sad to see that he has refused our help."