Bryan Ruiz netted an 89th-minute winner as Eredivisie leaders FC Twente held off a fightback from NEC Nijmegen to remain two points clear at the top of the table.
The hosts went in front through John Goosens before a Kenneth Perez free-kick and strikes from Blaise N'Kufo and Miroslav Stoch saw Twente go 3-1 up. However, Bjorn Vleminckx scored after 41 and 45 minutes to pull NEC level before he was sent off after 55 minutes.
Ruiz then headed a late winner as Steve McClaren's side secured a 14th win from 16 games - and an 11th successive victory.
PSV Eindhoven remain in close pursuit after winning 2-0 at RKC Waalwijk. PSV's winning run in all competitions reached double figures as second-half headers from Jonathan Reis and Danko Lazovic accounted for the Eredivisie's bottom team.
Third-placed Ajax slipped off the pace with a 2-0 defeat at FC Utrecht. The visitors offered little in the way of attacking threat over 90 minutes and Utrecht ran out deserved winners thanks to second-half strikes by Jacob Mulenga and Jan Wuytens.
A miserable afternoon for Martin Jol's Ajax was compounded late on when Vurnon Anita was given his marching orders for a second yellow card.
Feyenoord came from behind to defeat FC Groningen 3-1. Fourth-placed Feyenoord would have been confident of three points going into the match but they were behind in only the fourth minute as Koen van de Laak struck the opener.
It stayed that way until the eighth minute of the second half, when Stefan Babovic levelled, and further goals from Roy Makaay and Jon Dahl Tomasson earned the hosts the three points.
In today's other game, Heracles maintained their fine start with a 3-1 win against Heerenveen which moved them up to sixth. A Mark Looms header and a Willy Overtoom penalty put the home side in total control. Heerenveen pulled one back through a Oussama Assaidi strike but Heracles sealed it when Bas Dost netted late on.