Holders Manchester United will face Tottenham in the quarter-finals of the Carling Cup next month.
Chelsea - who saw off Bolton to reach the last eight - face another team from the north west as they bid to reach the semi-finals. Carlo Ancelotti's men take on Blackburn at Ewood Park.
Arsenal, conquerors of Liverpool in midweek, will face Manchester City at Eastlands.
And the draw, featuring eight teams from the Barclays Premier League, is completed by Portsmouth's clash with Aston Villa at Fratton Park.
Full quarter-final draw:
Blackburn v Chelsea
Man Utd v Tottenham
Portsmouth v Aston Villa
Man City v Arsenal
Matches to be played week beginning November 30