Tranmere have sacked manager John Barnes and his assistant Jason McAteer.
The duo took charge at Prenton Park in June, but a run of just two league wins from 11 matches has left Rovers languishing 22nd in League One.
Physio Les Parry has been placed in temporary charge and he will be assisted by reserve-team boss Shaun Garnett, with Tranmere not playing until Monday night against Stockport.
Chairman Peter Johnson said: "Unfortunately results have not gone our way this season and we are at the wrong end of the table.
"We must now focus on finding the best possible candidate to help us climb the division.
"I urge all supporters to get behind Les, Shaun and the team on Monday night when we play at home to Stockport County.''