Hull City boss Phil Brown looked on as his weakened side were destroyed 4-0 by a rampant Everton at the KC Stadium.
Brown made nine changes from the team that lost to Birmingham at the weekend and was punished for fielding such an under-strength team as the Toffees netted three inside the first 24 minutes.
Yakubu, in his first game back after a 10-month injury lay-off, Jo and Dan Gosling effectively settled the game before Tigers' fans even had time to digest their pre-match pie. Leon Osman added a fourth in the second-half as Everton cruised into the fourth round.
A powerful strike from youngster Danny Welbeck gave defending champions Manchester United a 1-0 victory over Wolves, despite the home side playing more than an hour with ten men.
United started the brighter of the two teams with Michael Owen, in only his second start of the season But when Fabio was sent-off for a challenge that would have looked more at home on a rugby pitch, it looked like Wolves may have had a chance.
But even with ten men United looked dangerous going forward and despite some good spells of possession for Wolves, the away side were undone by an excellent finish from Welbeck after the teenager latched on to an intelligent through ball from Owen.
Joe Cole marked his long-awaited return from injury by creating the goal that swept Chelsea into the Carling Cup fourth round at the expense of QPR at Stamford Bridge.
Cole was handed the captain's armband for his first appearance since a cruciate ligament injury in January as boss Carlo Ancelotti made 10 changes to the side that beat Tottenham at the weekend.
Florent Malouda was the only first-teamer to keep his place but the home side still had too much for Rangers with Cole setting up Salomon Kalou to slot the only goal of the game in the 52nd minute.
Peter Crouch was Tottenham's hat-trick hero as they bounced back from their weekend disappointment against Chelsea to rout Championship side Preston 5-1 at Deepdale.
Crouch opened the scoring in the 15th minute and added his second deep in the second half after Jermain Defoe (37) had given Spurs a comfortable half-time advantage.
Chris Brown pulled one back for Preston on 83 minute but substitute Robbie Keane struck the visitors' fourth in the 87th minute before Crouch completed his hat-trick in the last minute.
Gabriel Agbonlahor swept home a third-minute cross from John Carew and that proved enough for Aston Villa to squeeze past Cardiff at Villa Park.
James Milner hit the post with a penalty and the Bluebirds battled hard throughout but the Premier League outfit proved too strong as Agbonlahor netted for the fourth successive game.
Captain Kolo Toure netted an extra-time winner for Manchester City, as Mark Hughes' men came from behind to edge out Fulham 2-1 at Eastlands.
Gareth Barry had earlier cancelled out Zoltan Gera's spectacular first-half effort to leave the scores level at 1-1 after 90 minutes. But Toure's header, his first goal since joining from Arsenal, booked City's passage into the last-16.