A late goal from NEC Nijmegen midfielder Lorenzo Davids condemned Dutch champions AZ Alkmaar to a surprise 1-0 home defeat.
The former Feyenoord man struck three minutes from time to clinch NEC's second Eredivisie victory of the season, and their first on the road, to move the Nijmegen outfit up to 10th in the standings.
AZ remained fifth having picked up 12 points from their first seven games.
Elsewhere, a second-half Mads Junker brace secured Roda JC a 2-0 home victory over NAC Breda.
Junker headed his side in front nine minutes after the restart and doubled their advantage three minutes later.
Vitesse Arnhem claimed their second league win of the season with a 3-1 home triumph over promoted RKC Waalwijk.
Lasse Nilsson put the hosts in the ascendancy in the third minute, but that goal was cancelled out in the 24th minute by Fouad Idabdelhay - moments after RKC defender Gijs Luirink had seen his penalty saved.
Vitesse got their noses back in front through a Santi Kolk penalty seven minutes before the interval, however, and Paul Verhaegh sealed matters with the third four minutes into the second half.
Darl Douglas' second-half equaliser earned a 1-1 draw for Heracles Almelo at home to Sparta Rotterdam.
Dele Adeleye had put the visitors ahead on the stroke of half-time but parity was restored in the 63rd minute.
Sparta were reduced to 10 men in the 75th minute when Emmanuel Boakye was given his marching orders for a second bookable offence.