Tottenham continued their 100% start to the season with a 2-1 victory over Birmingham, but Redknapp saw Ledley King suffer a groin strain which forced him to substitute his key central defender at half-time, while influential midfielder Luka Modric limped off in the second half with a "nasty" leg injury.
Modric had a scan on Saturday night which revealed a break and, while the Croatian will be out of Premier League action for some time, he will also miss his country's World Cup qualifier at Wembley a week on Wednesday.
He told the Croatian daily Jutarnji List: "It's like my whole world has crumbled because I will be out for at least six weeks. I am terribly sad. It wasn't a ferocious tackle but it hurt awfully and I knew something was wrong the moment it happened.
"The worst feeling is knowing that I will be watching both my club and country from the sidelines for a while."
A club statement confirmed his break, but stated that the player should be back in training sooner than first expected: ''Luka Modric suffered a fracture to his fibula on Saturday which does not require surgery and simply requires the wearing of an aircast protective boot,'' it read. ''It is anticipated Luka will be back in training after six weeks.''
Tottenham are already suffering with injuries and Redknapp confirmed even before he knew the extent of the problem that his squad are thin on the ground.
He said: "Ledley has done his groin and we don't know how long he will be out yet. But Modric's looked like a nasty injury. If we lose Ledley and Modric with Michael Dawson and Jonathan Woodgate already out, the squad is a bit short."