Daniel Agger will travel to France for back surgery next week and is likely to be out for six weeks, missing Monday night's clash with Aston Villa at Anfield.
The Liverpool defender has missed the first two Premier League games of the season, having been troubled with the injury all summer. Liverpool have been severely stretched with Martin Skrtel also sidelined because of a jaw injury.
However, boss Rafael Benitez drafted in Greek international defender Sotirios Kyrgiakos from AEK Athens for £2m on Thursday to strengthen his squad.
Kyrgiakos should be available to make his debut in next Monday night's game against Aston Villa.
Benitez also has the option of drafting in 19-year-old Spanish defender Daniel Ayala, who partnered Jamie Carragher in Wednesday night's 4-0 Premier League win against Stoke.