Blaise Nkufo scored a 64th-minute goal to earn Steve McClaren's Twente Enschede a 1-0 win at ADO Den Haag which put them top of the Dutch league on Saturday.
McClaren is in his second season in charge of the Dutch club after being sacked as England coach when they failed to reach the Euro 2008 finals.
The Englishman guided Twente to second place last season but has already suffered disappointment this season after Twente were eliminated in the Champions League qualification round by Portugal's Sporting earlier this month.
Ronald Koeman's AZ Alkmaar, last season's surprise champions, thrashed newcomers RKC Waalwijk 6-0 with Maarten Martens netting twice.
Last year's top scorer Mounir El Hamdaoui opened the scoring after 15 minutes, picking up a pass from Moussa Dembele to beat goalkeeper Jurgen Wevers.
Belgian international Dembele doubled the lead early in the second half before an own goal by Hans Mulder made it 3-0.
Martens's double and Jeremain Lens completed the rout for Alkmaar, who are fourth with six points from three matches.
Twente are top with seven points from three games, one ahead of Ajax Amsterdam and Utrecht who are in action on Sunday against PSV Eindhoven and VVV Venlo respectively.
Sparta Rotterdam collected their first win of the season by beating Willem II Tilburg 2-1.