Tevez is due to start training following a heel injury and will miss the warm-up game against Rangers at Ibrox on Wednesday.
Argentina's doctor has been to Carrington to check on Tevez's progress with coach Diego Maradona set to name his squad for the game in Moscow.
Hughes is hoping Tevez will be fit for the opening Premier League game at Blackburn and told the club's website: "We don't think Carlos should play for his international team. We would prefer him to stay back next week.
"The Argentina doctor came over and he'll be speaking to Maradona on Tuesday. He'll probably want to check and see how Carlos is now. Ideally, I'd prefer that he wasn't selected. He's not trained all pre-season.
"He had an injury from his last international then banged the same area when he slipped in the shower. He'll be fine for the start of the season, but he's still not able to put his full weight on it.''
England midfielder Gareth Barry trained on Tuesday for the first time in almost a week after a foot injury and is expected to get a run-out against Rangers.