San Luis vice president Ricardo Perez Amaral has slammed the decision by the South American Football Confederation to force Mexican teams to play home games in the last 16 of the Copa Libertadores in Colombia following the outbreak of the swine flu epidemic.
The South American Football Confederation (CONMEBOL) have confirmed San Luis and Guadalajara will play their home ties at Bogota's Estadio El Camping on May 6.
Argentina's Boca Juniors, who are potential opponents of San Luis depending on results, submitted a report to CONMEBOL requesting the change of venue.
"This decision will affect us and we are quite disappointed about not being able to play in our home after we clinched the qualification in a quite dramatic way," said Perez Amaral.
"It is historic because this is San Luis' first Copa Libertadores appearance and, even though we believe the CONMEBOL decision has valid reasons, we believe there were other possible options such as changing the home condition like Mexico did with Jamaica when that country had a problem.
"Based on fair play, we wanted to change the home condition to have some time for the country to return to the normal way of living, but we know the main opponents to this option was Boca Juniors so they made the decision that affects us and leaves the city of San Luis Potosi without the chance of hosting a historic match."
In September, the World Cup qualifier between Mexico and Jamaica was rescheduled after Jamaica was affected by Hurricane Gustav.