Liverpool surrendered their unbeaten record as Harry Redknapp continued his miracle working at Tottenham Hotspur.
When Dirk Kuyt scored in the 3rd minute it seemed the Reds were making serene progress in their hunt for a first title in 19 years. So it looked for the first half but Redknapp half-time teamtalk/cup throwing paid off.
Jamie Carragher could only head into his own net in the 69th minute and then, with the game in injury-time, sub Roman Pavlyuchenko stole on to a Zokora pass to make it a wondrous week since Redknapp took the White Hart Lane reins.
Arsenal's season looks in serious danger of not including a title challenge after a 2-0 defeat to Stoke City. After the late denouement against Spurs on Wednesday the Potters clearly believed that the Gunners were there for the taking. Ricardo Fuller opened the scoring from a trademark Rory Delap throw-in. Seyi's goal in the 73rd minute came from the same source and added to Arsenal's woes, made worse by Robin Van Persie's sending off.
Gael Clichy gave Arsenal a foothold in the game but time ticked on for nine-man Arsenal - Theo Walcott limped off - and Stoke secured a famous win.
Another promoted side in Hull City nearly pulled off their own amazing result when they mounted a comeback against Manchester United. The champions had seemed to be making serene progress when 4-1 up after Cristiano Ronaldo smashed a brace, and Michael Carrick, back from injury and a Nemanja Vidic strike from a corner. But Bernard Mendy and a Geovanni penalty added to Daniel Cousin's goal to make it 4-3 and United were left to chew their fingernails before the referee blew his whistle.
No such trouble for Chelsea who simply blew away Sunderland at Stamford Bridge with a 5-0 win. A Nicolas Anelka hat-trick and goals from Alex and Frank Lampard confirmed the Blues' superiority over Roy Keane's side. Chelsea went top and await news from White Lane of Liverpools' progress against Spurs.
Portsmouth are still without a win without Harry Redknapp. Tony Adams' charges looked to have secured a point when Niko Kranjcar cancelled out an Amir Zaki penalty. But Emile Heskey scored an injury-time winner to score his 100th Premier League goal and get a vital win for Wigan.
It was also a late show for Blackburn for whom Keith Andrews secured a point with a late equaliser at West Bromwich Albion. Benny McCarthy had a mixed afternoon in scoring a penalty and being later sent off and goals from Roman Bednar and Ishmael Miller looked set to give the Baggies the spoils. Until Andrews had his say in the 89th minute.
On a day of tardy scoring it was an 84th minute Mido goal that secured Middlesbrough a home point against West Ham, for whom Hayden Mullins had scored.
In the early game, Louis Saha set a trend for the day when coming on a substitute to score the winner for Everton against Fulham, who are deep in relegation trouble.