Mexican side Pumas advanced to the CONCACAF Champions League's quarter-finals after beating Houston Dynamo 3-1 at Robertson Stadium on Wednesday.
Juan Carlos Cacho put the Pumas ahead in the 18th minute from the penalty spot while Fernando Espinoza doubled the advantage on the half-hour mark.
Nate Jaqua reduced the deficit before halftime but Marco Palacios made sure of the victory 20 minutes before time.
Thanks to this triumph Pumas moved top of Group B with nine points, four ahead Dynamo and Panama's San Francisco, who defeated Salvadorians Luis Angel Firpo 3-2 at home.
Temistocles Perez, Christian Sanchez and Patricio Gomez netted for the winners while Dennis Alas and Eduardo Gimenez for Firpo.
In the sixth round, the last of the group stage, Pumas will entertain San Francisco and Houston Dynamo will visit Luis Angel Firpo.
Meanwhile, in Group C, Mexican champions Santos Laguna obtained a crucial triumph in their battle for qualification as they defeated Panama's Tauro 3-0 at home.
Ecuadorian midfielder Christian Benitez was the star of the game as he scored twice, while Gregorio Torres completed the scoring for the winners.
Both teams ended the match with nine players with Matias Vouso and Alberto Soto sent off for Santos and Ricardo Amor and Joan Melo red carded for Tauro.
"I have to recognise that Santos deserved the win but I have to say that the performance of the referee was a disaster," said Tauro's coach Miguel Mansilla.
Santos are top of Group C with nine points, two ahead of Tauro and Puerto Rico Islanders, who on Thursday will clash with already-eliminated Municipal in Guatemala.