Dirk Kuyt scored a late winner after his shanked volley squeezed over Wigan's goal-line to hand the Reds a dramatic 3-2 victory at Anfield.
Kuyt's winner stole the limelight from Amir Zaki who put the visitors ahead twice, scored a goal of the season contender but still ended up on the losing side.
Antonio Valencia was sent off for a second bookable offence with fifteen minutes to go before Albert Riera levelled things up at 2-2.
Then with just five minutes remaining Kuyt popped up in the area to mishit a volley that sneaked over the line via the post.
Arsenal also had to come from behind to win 3-1 at home to Everton after Leon Osman gave the Toffees a first half lead.
Samir Nasri equalised before a Robin van Persie header edged them in front. Theo Walcott tucked home a third late in the game as Everton's miserable run of form continued.
Wayne Rooney's irrisistable form continued as he scored the opener and set up two more goals as Manchester United demolished West Brom 4-0 at Old Trafford.
Ronaldo, Dimitar Berbatov and Nani added the other goals as United moved into the top four.
Aston Villa and Portsmouth cancelled each other out at Villa Park with defences on top in a game of few chances.
Fulham and Sunderland played out a goalless draw at Craven Cottage, though Roy Keane was livid after Kieran Richardson's free kick was ruled out for a foul in the penalty area.
Djibril Cisse also came close to breaking the deadlock after rattling the crossbar from 25 yards.
Bolton and Blackburn's game at the Reebok Stadium also finished 0-0, after Andy O'Brien fluffed a great chance to win the game deep in the second half.
Earlier in the day. Chelsea battered Middlesbro' 5-0, and it could have been more. Salomon Kalou fired the visitors ahead with 14 minutes gone, before Juliano Belletti to increase their lead with a stunning 35-yard strike.
Kalou made sure of the points with a deflected 53rd-minute third, and Frank Lampard and Florent Malouda completed the rout on a day when Nicolas Anelka had a goal disallowed, hit the post and was denied by keeper Ross Turnbull.