Manchester United midfielder Paul Scholes suffered medial ligament damage in Tuesday's Champions League victory at Aalborg and will be out for 10 weeks, the club have confirmed.
Meanwhile, Fabio Capello will be a more than interested observer of Wayne Rooney's ankle injury, which may be a cause for concern for England.
Rafael Da Silva's first Champions League start also ended with him limping off the field while goalscorer Rooney left proceedings feeling pain in his ankle.
Sir Alex Ferguson has already virtually written him out of United's league encounter with Blackburn at Ewood Park on Saturday.
"Wayne felt his ankle," confirmed Ferguson.
"We hope it is not ligament trouble - but he is doubtful for Saturday, I would imagine."
Capello is due to name his England squad for the World Cup qualifiers with Kazakhstan and Belarus on Sunday and ligament damage would surely rule Rooney out of both.
Scholes is unlikely to be available again until the visit to Tottenham on December 13, which comes immediately before United head to Japan for the World Club Championship.
It means Scholes will miss the rest of his side's Champions League group campaign, plus key Premier League away games at Everton, Arsenal and Manchester City.
In total the 33-year-old could miss 16 matches from United's season and Michael Carrick and Owen Hargreaves are currently on the sidelines too.