Bordeaux visit Grenoble on Saturday looking to get their season back on track after a series of disappointing recent results.
Les Girondins, Ligue 1 runners-up last season, have been tipped by many pundits to run champions Lyon close again this term but they have struggled for their best form over the past six weeks.
Domestically, they are 10th in the standings and already six points off the pace - predictably set by Les Gones.
To make matters worse, they were thumped 4-0 by Chelsea on Tuesday in their opening Champions League group-stage match.
Promoted Grenoble will be no pushovers, having lost just once this season and sitting pretty in fourth spot, but Bordeaux defender Souleymane Diawara wants a reaction this weekend.
"It's true that this result (against Chelsea) is a continuation of what we have shown so far this season," said the centre-back.
"We must bounce back very quickly because once doubts start to creep in, you are dead."
Coach Laurent Blanc added: "We lack aggression and we have therefore become weak. We have to work hard and refocus."
Lyon's 3-2 win over Nice last weekend, secured courtesy of a controversial stoppage-time penalty by Karim Benzema, put them clear at the top by two points from Marseille, who drew 1-1 with Bordeaux last Saturday.
Les Gones will get the chance to extend their lead over OM to five points, for 24 hours at least, as they take on Le Havre on Saturday and Marseille host Monaco in Sunday's late fixture.
Marseille and Lyon are the only two teams yet to be beaten in the league this season.
At the other end of the table, St Etienne coach Laurent Roussey will be desperate for a victory over Paris St Germain to get his side's campaign back up and running.
The vultures are circling with Les Verts having lost four of their opening five matches, the latest being a 2-0 defeat at Caen which left them third from bottom on just three points.
Both ASSE and PSG are in UEFA Cup duty on Thursday night so their match is on Sunday, as is Nancy's home match with Rennes - France's two other participants in Europe's second-tier club competition.
All the other matches in Ligue 1 this weekend are on Saturday.
Rock-bottom Nantes, still on just one point, welcome Valenciennes while second-bottom Sochaux - who are a point better off than Les Canaris - travel to Toulouse.
Elsewhere, Caen visit Lorient, Lille entertain Auxerre and Nice host Le Mans.