Adriano will return to Serie A side Internazionale after the latest round of South American World Cup Qualifiers, Sao Paulo president Juvenal Juvencio revealed on Tuesday.
The Brazil striker fell out of favour with then Inter boss Roberto Mancini in 2007 and was sent on loan to Sao Paulo in order to regain form and fitness.
Adriano's performances at Estadio Morumbi has won him a Brazil recall and he is now eager to return early from his loan, which was due to end on July 10, to impress new Inter boss Jose Mourinho.
'The contract will be rescinded,' Juvencio said. 'He asked us for a resting time to return to European football and we accepted.'
Before going back to Milan, Juvencio revealed Adriano will meet his Sao Paulo team-mates and club officials.
'We wanted to organise a farewell celebration but it will not be on the field,' he said.
Sao Paulo coach Muricy Ramalho accepted the president's decision as he believes the attacker was becoming distracted by thoughts of Inter.
'His mind was not here,' said Ramalho. 'It's obvious. Adriano's focus is somewhere else. He helped Sao Paulo a lot, but his time is over. We must remember the good things he did.'
Adriano's last match for Sao Paulo was on May 21, when the club lost 3-1 to compatriots Fluminense in the quarter-finals of the Copa Libertadores.
He scored six goals in South America's premier club football tournament this season.