Carlos Hernandez became the third player to be removed from Costa Rica's World Cup qualifying squad to face Grenada due to injury.
The Melbourne Victory midfielder suffered a muscle tear during a friendly against Juventus last Friday and doctor Alejandro Ramirez announced his withdrawal.
Saprissa's Michael Barrantes has been drafted into the squad by coach Hernan Medford ahead of the qualifiers.
Medford had already been forced into making a double change to his initial squad after Alajuelense defender Harold Wallace replaced Brujas midfielder Danny Fonseca, who suffered a knee injury.
Meanwhile, right-back Try Bennett had been added to the squad in place of Jervis Drummond who had been withdrawn with a shoulder injury.
The Costa Rica coach will also check on the availability of two other players after forward Ronald Gomez and defender Cristian Montero were left facing late fitness tests.
The Ticos travel to Grenada on June 14 for the first leg of the CONCACAF Zone's second round with the return match to be played in San Jose a week later.
Costa Rica squad: Gonzalez (Herediano), Alfaro (Alajuelense), Navas (Saprissa); Wallace (Alajuelense), Umana (Liberia), Bennett, Badilla, Cordero, Nunez (four Saprissa), Montero (Alajuelense), Segares (Chicago Fire), Harris (Brujas), Gonzalez (Herediano), Diaz (Wisla Krakow); Lopez, Borges, Alonso, Barrantes (all Saprissa), Azofeifa, Ruiz (both Gent), Bolanos (Odense); Alpizar, Gomez (Saprissa), Nunez (Alajuelense), Saborio (Sion)