Darren Fletcher insists Manchester United are out for revenge after the 'battle of Stamford Bridge' and last season's FA Cup final defeat to Chelsea.
Avram Grant's side beat United in a tempestuous league encounter last month but the Scottish midfielder believes United are well placed to hit back.
Victory over Wigan in their final Premier League game on Sunday will see United almost certainly pip the Blues, who are level on points but way behind on goal difference, to the title.
The sides also meet again in the Champions League final in Moscow in a fortnight.
Fletcher said: 'We owe Chelsea one. We lost the FA Cup final and then lost the league game the other day, though we managed to win at Old Trafford.
'If we can win the league it will give us great momentum to take into the Champions League final.
'Pipping Chelsea to the league and winning it for the second year in a row would give us great confidence.'
Wigan, however, insist United's trip to the JJB Stadium will not be a stroll to the title, with even club owner Dave Whelan having his say.
'Certainly the dressing room has been buzzing all week as the players are determined to unsettle United,' Whelan said.
Midfielder Mikel John Obi has given his backing to under-fire Chelsea boss Avram Grant ahead of their crucial final game against Bolton at Stamford Bridge.
Mikel refuses to accept that the title will remain at Old Trafford for the second successive season.
The Nigerian said: 'He's a nice man, the perfect guy, I like him.
'We have a pretty good chance in the Premier League, and in the Champions League as well.
'In the last game United may drop two points and if we win against Bolton we win the title.'
Bolton boss Gary Megson is expected to begin ringing the changes as soon as the final ball of his team's hair-raising season has been kicked.
Barring a mathematical catastrophe, Megson's men ended their relegation fears with victory over Sunderland last week.
Megson said: 'I've promised the players as soon as we definitely know what's happening to us, we'll look at what's going to happen in the future.
'We've explained to the players out of contract that we can't do anything until we're safe. The same has happened with pre-season and the games we might play and the trips we might make.
'Everything has been put on the back-burner to try to get enough points to stay up. If we can achieve that this weekend there will be a lot of work done quickly to start planning for next season.'
Sunderland boss Roy Keane insists there is no shortage of challenges for clubs outside the 'big four'.
Keane's Newcastle counterpart Kevin Keegan sparked a major debate this week when he highlighted the gap between the Premier League's top four and the rest.
'We all have different challenges,' said the Irishman, whose side face Arsenal on Sunday. 'We can't compare ourselves to the Arsenals or the [Manchester] Uniteds or anything like that.
'But we certainly want to be competing with the teams ahead of us. If you feel you can't challenge the top boys for the league, you certainly want to do better for the cups.'
Gunner boss Arsene Wenger looks set to give another of his youngsters a chance at the Stadium of Light.
Having already played Polish keeper Lukasz Fabianski and Brazil teenager Denilson in the last two games, Wenger could now give 18-year-old midfielder Kieran Gibbs an opportunity.
'I could give one or two players an early breather because they go to Euro 2008 or the African qualifiers,' the Frenchman said.
'So Kieran Gibbs, who got on the bench last weekend, could be involved again, so could Mark Randall.'