Portsmouth central defender Sol Campbell has pulled out of England's squad for the friendly with Germany at Wembley on Wednesday because of a groin injury.
Campbell, selected for the first time since Steve McClaren took charge of England last year, missed Portsmouth's 3-1 victory over Bolton Wanderers on Saturday and manager Harry Redknapp told BBC Radio the player had withdrawn from the squad.
It is sorry news for Campbell who had been recalled to the England fold alongside team-mate David James.
His absence leaves McClaren with a problem in central defence with Ledley King and Jonathan Woodgate injured and captain John Terry also a fitness doubt.
Newcastle's Steven Taylor, who is in the senior squad for the first time, may be the beneficiary as he eyes a debut.