Valencia's David Silva cracked home a late equaliser to deny Inter Milan and hand the Spanish side a 2-2 draw from their trip to the San Siro.
Silva volleyed home with just four minutes remaining to give the Primera Liga side an away goals advantage ahead of the Champions League last-16 second leg at the Mestalla in a fortnight's time.
It was a better result than performance for Los Che, who were second best for much of the contest against an Inter side which failed to capitalise on their superiority.
Esteban Cambiasso headed the hosts in front after 29 minutes only for David Villa to fire home a spectacular equaliser with a 30-yard free-kick in the second half.
Brazilian full-back Maicon looked to have won it for Inter when his marauding run and composed finish put the Nerazzurri back in front, but Valencia displayed the stubbornness which has seen them surge up the Primera Liga table recently by finding a second equaliser.
Lyon's trip to Roma's Stadio Olimpico finished with honours even as both sides failed to find a cutting edge in the final third.
The game finished goalless and neither side found their rhythm in a tense affair which was interrupted by a series of free-kicks and 11 yellow cards from English referee Mike Riley.
The opening stages produced scrappy play from both teams, with a succession of fouls denying the crowd the chance to see any meaningful attacks
A Juninho free-kick gave the visitors one of the best when home midfielder Rodrigo Taddei headed the ball onto the right post from the centre of a crowded penalty area.
Both sides had chances as the match wore on but it was Lyon that nearly stole it when another free-kick from Juninho, this time in the last minute, dipped just too late and landed on the roof of the net.