Wigan have confirmed they are to write an official letter of complaint to the Premier League, the Football Association and referees' chief Keith Hackett in relation to the conduct of referee Phil Dowd during Sunday's 2-1 Premiership defeat at Arsenal.
Jewell has also vowed to launch a vigorous defence of himself after being charged with improper conduct by the FA.
Jewell launched an on-the-pitch broadside at Dowd in the wake of Sunday's game, with the 43-year-old seen pointing an accusing finger.
English football's governing body are also looking into Jewell's post-match comments in which he roundly condemned the performance of Dowd.
Jewell is determined to clear his name, and has already requested a personal hearing.
'We, as a club, will be fighting this tooth and nail,' insisted Jewell.
'We owe it to our supporters to fight this, because if I just shrug my shoulders and do nothing when I feel an injustice has been done, it would be letting them down.
'I have been overwhelmed with the support I have had from inside the game, big figures who I respect a great deal.
'They have told me in no uncertain terms that I must take this all the way, and that's what I intend to do.'
Jewell was incensed the Latics were denied an 80th-minute penalty when Emile Heskey was fouled by Mathieu Flamini inside the area.
That could have led to Wigan taking a 2-0 lead and a red card for Flamini, however, Dowd apparently claims he saw nothing illegal between two players.
Within seconds, Dowd further angered Jewell by not letting Josip Skoko back onto the pitch after he had received treatment.
The Australian was left on the sidelines as Fitz Hall scored the own goal which led to Arsenal's comeback win, with Flamini setting up the equaliser from an offside position.
After the game, Jewell said Dowd made 'a catalogue of mistakes.'
He added: 'I have only blamed referees three times this season, and he (Dowd) has been in charge every time .
'He is telling our players to F-off and stuff, which I do not mind because it is a man's game - but then he is telling me that I will be sent into the stands for having a go at him.
'It cannot all be one-way.
'If he wants to take my conduct to the authorities, then I will take his language to my players to the authorities as well.
'I am sure I will have to explain my comments to the Football Association - but if I do, I will just show them a video of the game.'
Jewell further berated Dowd by saying: 'He has cost our team the points - it could cost us £50million.
'Referees just do not realise the significance of football matches.
'I think some of them consider it to be more of a hobby and they do not take it as seriously as we do as managers and players.
'I just do not understand where they are coming from.'