Spain beat England 1-0 in an exhibition game at Manchester on Wednesday night behind Andres Iniesta's goal in the 63rd minute.
It was the first international goal for Iniesta, who entered in the 55th minute. He collected a clearance from defender Rio Ferdinand and beat goalkeeper Ben Foster with a long-range shot.
"My goal was an important one for me," Iniesta said. "It was a friendly but it was one against a team like England, which is always physical."
Fans booed as England's players came off the field at Old Trafford.
"We just lacked that bit of quality, that final ball," England coach Steve McClaren said. "It's very difficult in friendly like this when you have to make changes and fit different people in."
Germany, Argentina and the Netherlands also won exhibition games, and Ireland won 2-1 at San Marino 2-1 in the night's only 2008 European Championship qualifier.
At Duesseldorf, Germany beat Euro 2008 co-host Switzerland 3-1, getting goals from Kevin Kuranyi, Mario Gomez and Torsten Frings. After the World Cup semifinalists built a three-goal lead, Marco Streller scored for Switzerland in the 71st.
At Saint-Denis, Javier Saviola scored in the 15th minute to give Argentina a 1-0 victory at France.
At Amsterdam, Ryan Babel, Welsey Sneijder, Joris Mathijsen and Raphael van der Vaart scored to lead the Netherlands to a 4-1 victory over Russia, which got a goal from Vladimir Bystrov.
At Serravalle. Stephen Ireland scored in the fourth minute of second-half injury time to give Ireland a 2-1 victory over San Marino. Kevin Kilbane gave Ireland the lead in the 49th minute, but Manuel Marani tied it in the 86th for San Marino, which hasn't gotten a point in European qualifying since 1990.
Ireland (2-2-1) moved past Slovakia (2-2) into third place in Group D behind Germany and the Czech Republic (each 3-0-1). San Marino had been outscored 25-0 in its three previous qualifiers.
At Brussels, Jan Koller scored in the sixth minute and set up Marek Kulic's goal in the 74th as the Czechs beat Belgium 2-0. It was the 48th goal in 75 international appearances for Koller, who scored the Czechs' first goal against the United States during last summer's World Cup.
Maksym Kalinichenko scored off the rebound of his own penalty kick in the 74th minute, giving visiting Ukraine a 1-1 tie at Israel, which had gone ahead on Walid Badier's goal in the 38th.