Giggs returns for United, Flamini replaces Gilberto
Premiership leaders Manchester United arrived at the Emirates Stadium knowing victory over Arsenal would open a nine-point advantage over Chelsea.
United manager Sir Alex Ferguson brought Ryan Giggs back into the side for Park Ji-Sung in the only change from last weekend's 3-1 home victory over Aston Villa.
• LIVE COMMENTARY: Arsenal v Manchester United
Mathieu Flamini came into the Arsenal midfield for Gilberto, who was suspended after being sent off early in the Gunners' 2-0 win at Blackburn.
Emmanuel Adebayor, who scored the winning goal against United at Old Trafford in September, replaced Robin van Persie up front while Emmanuel Eboue started at right-back ahead of Justin Hoyte.
Arsenal: Lehmann, Eboue, Toure, Senderos, Clichy, Hleb, Fabregas, Flamini, Rosicky, Adebayor, Henry.
Subs: Almunia, Julio Baptista, Van Persie, Denilson, Hoyte.
Man Utd: Van der Sar, Neville, Ferdinand, Vidic, Evra, Ronaldo, Scholes, Carrick, Giggs, Rooney, Larsson.
Subs: Kuszczak, Heinze, Brown, Saha, Fletcher.