On-loan striker Henrik Larsson started to repay Sir Alex Ferguson's faith with a debut goal as Manchester United sent Aston Villa tumbling out of the FA Cup thanks to an injury-time mistake from Gabor Kiraly.
The Aston Villa goalkeeper let a regulation shot from substitute Ole Gunnar Solskjaer slide under his body in the 91st minute after goals from Larsson and Milan Baros had cancelled each other out.
Larsson had shown a handful of nice touches without causing too much trouble in the Villa defence before he scored in the 55th minute.
The former Celtic and Barcelona forward took control of Wayne Rooney's centre, flicking the ball up before firing right-footed past Kiraly to open his United account.
Ryan Giggs then struck the crossbar with a free-kick but Villa rallied, going close on a number of occasions before substitute Baros received the ball eight yards from goal, before rifling his shot low past deputy United keeper Tomasz Kuszczak.
But Kiraly ensured that it would be Ferguson's men who progressed to the fourth round, when he made a mess of Solskjaer's late strike.
A first-half blitz from Blackburn helped put Everton out of the competition at the first hurdle, as Rovers won 4-1 at Goodison Park.
Cardiff and Tottenham played out a miserable goalless draw at Ninian Park, with chances hard to come by at both ends.
Michael Chopra had the best opportunity of the match when he intercepted Young-Pyo Lee's weak header, but the former Newcastle man rolled the ball wide with Spurs goalkeeper Paul Robinson advancing.
The Premiership side failed to create anything of note and will be hoping for better luck when the Bluebirds travel to White Hart Lane for the replay.
Rovers striker Matt Derbyshire, who spent much of last season on loan at League Two Wrexham, scored his second goal in a week as Mark Hughes' side scored three times in the first 38 minutes.
Derbyshire followed up his strike against Wigan on New Year's Day with a regulation finish after Tim Howard spilled Morten Gamst Pedersen's effort.
Pedersen then gave Howard no chance after 21 minutes, drilling home a 25-yard drive before Paul Gallagher made it three before the break.
Everton's consolation came in the second half when Andrew Johnson converted a 69th-minute penalty.
Benni McCarthy finished things with his 13th strike of the season in stoppage time.
Sheffield Wednesday hit back from a goal behind to draw 1-1 with Premiership opponents Manchester City.
Steven MacLean grabbed the equaliser just moments after going behind when he lashed the ball past Nicky Weaver from 20 yards.
Georgios Samaras scored the opener from the spot after Micah Richards was brought down by Kenny Lunt.
Wednesday, on top for large periods of the match, had chances to win it late on as Maclean and Wade Small had opportunities but City held out for a replay.