Arsenal sent holders Liverpool tumbling out of the FA Cup at the first hurdle, with Tomas Rosicky scoring twice in the Gunners' 3-1 victory.
The Czech midfielder scored a superb opener in the 37th minute, taking control of Alexander Hleb's pass before firing high beyond Jerzy Dudek in the Liverpool goal.
Rosicky scored again seconds before half-time, beating Dudek from 20 yards to put Arsenal firmly in control.
Dutch striker Dirk Kuyt pulled one back, heading home for the hosts 20 minutes from time, but fit-again Arsenal captain Thierry Henry ended any hopes of a comeback in the 84th minute.
The Frenchman took advantage of some slack defending on the left flank to win possession before surging at the Liverpool back four and scoring with a low drive.
The size of Alan Pardew's task at Barclays Premiership strugglers Charlton became even more apparent as they were dumped out of the FA Cup by Coca-Cola League One side Nottingham Forest.
Forest were on the wrong end of a 5-0 drubbing by promotion rivals Oldham last time out but put their own poor form behind them to create a fine cup upset.
The Addicks were woeful in defence and failed to create anything convincing in the final third as goals from Junior Agogo and Grant Holt put Forest in the fourth round.
Agogo nodded past Thomas Myhre - in because of Scott Carson's unavailability - before Grant Holt took advantage of some sleepy defending to power a second from Nicky Southall's free-kick.
Neil Warnock's understrength Sheffield United are also out, after slumping 3-0 at League One promotion-hopefuls Swansea.
Thomas Butler scored twice in six second-half minutes to punish the Blades for a sluggish display.
Adebayo Akinfenwa saw his shot blocked after 53 minutes but when the ball broke free Thomas Butler was first to react, sliding home from close range before following up with a left-foot finish after an hour.
Butler continued to impress and after 66 minutes he was felled by Derek Geary, resulting in a penalty that Leon Britton converted with ease.
Leicester scored in the 92nd minute to earn a 2-2 draw and a replay with Fulham.
Danny Cadamarteri was the scorer, firing home moments before the whistle after Moritz Volz's fine drive looked to have secured the Cottagers' place in the fourth-round draw.
American striker Brian McBride and Patrick Kisnorbo's goals cancelled each other out as the game picked up after a goalless first period.
Championship leaders Birmingham overcame to first-half dismissal of Radhi Jaidi to claim a last-gasp 2-2 draw against Newcastle.
FA Cup specialist Dudley Campbell opened the scoring and Steven Taylor levelled the scores before Kieron Dyer and Sebastian Larsson - four minutes from time - ensured the sides would meet again.
Substitute Nicky Forster got the goal ensured Phil Brown's Hull would be heading to Middlesbrough for a replay on the back of a 1-1 draw.
Australian striker Mark Viduka looked to have claimed the only goal of the game for Boro when Forster, on the field for just two minutes, headed David Livermore's centre past Brad Jones.
Chelsea ran out 6-1 winners over a Macclesfield side whose brave resistance came crashing down when goalkeeper Tommy Lee hauled down £30million striker Andriy Shevchenko inside the area.
Lee was sent off, Lampard converted the spot-kick to complete his hat-trick following two first-half goals and defender David Morley was forced to don the gloves.
John Murphy had briefly given Paul Ince's side hope making it 1-1 but goals from Shaun Wright-Phillips, Mikel John Obi and Ricardo Carvalho completed the rout.
West Ham, whose travails in front of goal looked set to continue after a goalless first half, found some form to win 3-0 over Brighton.
Mark Noble claimed the first after good build-up play from new signing Luis Boa Morte and Carlos Tevez left him with a simple finish inside the area.
Carlton Cole then scored for only the second time in his Hammers career before Hayden Mullins added a third.
Nothing could separate Portsmouth and Wigan for more than an hour but Kanu was the match-winner after Lee McCulloch had cancelled out Andrew Cole's opener.
With 25 minutes left, Andrew Cole, afforded a rare start by Harry Redknapp was in the right place to bury Sean Davis' cross from the right flank.
Premiership bottom club Watford secured a confidence-boosting 4-1 victory over Stockport despite conceding the first goal of the game, while Norwich beat non-league Tamworth by the same score in the early kick-off.
West Brom gave under-pressure Leeds no respite from their dispiriting league campaign, knocking them out with a 3-1 win at the Hawthorns.
Paul McShane got things off to the perfect start for Tony Mowbray's men after six minutes, leaving veteran strikers Kevin Phillips and John Hartson to make it three before a late Paul Robinson own-goal.
High-flying Preston edged out Sunderland 1-0 in another all-Championship clash, Brett Ormerod claiming the match-winner after 31 minutes.
Two other matches featuring two sides from the second-tier will go to replays with Southend drawing 1-1 with Barnsley and QPR fighting out a 2-2 draw with Luton.
Bristol City and Coventry will also meet again after drawing 3-3 in a free-flowing match at Ashton Gate, but Blackpool ended non-league Aldershot's involvement with a 4-2 win.
Bolton were the day's other big winners, running out 4-0 victors at mid-table League One side Doncaster.
Kevin Davies was first off the mark for Wanderers, finishing smartly from Stelios Giannakopoulos' looping pass.
He then turned provider setting up Andranik Teymourian to drive home powerfully from the edge of the box.
Idan Tal grabbed a third after 33 minutes with a shot that initially looked like it may not be given before the referee decided his shot had indeed crossed the line.
Teymourian scored his second of the game four minutes into the second period - and Rovers failed to get back into the tie.
Two goals in the last eight minutes ensured Coca-Cola Championship outfit Stoke a place in the fourth round of the FA Cup at the expense of battling Millwall.
The Lions are engaged in a fight against relegation in League One but put that behind them to push Tony Pulis' promotion hopefuls all the way at the Britannia Stadium.
City's John Eustace headed against the crossbar after 40 minutes but it was not until Marvin Elliott's 82nd-minute own-goal and Ricardo Fuller's strike five minutes later that the result was assured.
In the night's other match League Two side Bristol Rovers progressed with a 1-0 win over Hereford.
Just one point separates the sides in the league, with Graham Turner's Bulls just ahead of Paul Trollope's Rovers side.
Richard Walker was the matchwinner for the hosts, converting a 23rd-minute penalty following Wayne Brown's foul on Craig Disley.
FA CUP REPLAYS
Tuesday January 16th - kick-off 19:45 unless otherwise stated
Oldham Athletic v Wolverhampton Wanderers
Ipswich Town v Chester City
Coventry City v Bristol City
Plymouth Argyle v Peterborough United
Luton Town v Queens Park Rangers
Barnsley v Southend United
Middlesbrough v Hull City 20:00
Wednesday January 17th - kick-off 19:45
Fulham v Leicester City
Newcastle United v Birmingham City