In the top of the table clash, United and Chelsea shared the honours at Old Trafford. Louis Saha banished the memory of his missed penalty against Celtic on tuesday with a well taken effort after good work by Wayne Rooney but Ricardo Carvalho headed a second-half equaliser which gave Chelsea a point and kept things as they were at the top.
Ex-Gunner Nicolas Anelka decided to open his Bolton account with a pair of exquisite strikes to all but end Arsenal's title challenge. Abdoulaye Faye opened the scoring before the first of Anelkas' strikes. Gilberto Silva snatched one back to give Arsenal some hope but Anelka ended these in emphatic style during an entertaining game.
Spurs came from a goal down against Wigan at White Hart Lane to record an emphatic three-one win. Henri Camara opened the scoring for the visitors but Martin Jol's men responded with two goals in two minutes through the stike pairing of Jermaine Defoe and Dimitar Berbatov before Aaron Lennon wrapped up the points in the last minute.
Newcastle picked up a handy win against Portsmouth at St. James Park when Antoine Sibierski's goal gave the geordies their first win in ten. Harry Rednapp's side again froze on their travels and, but for David James in goal, would have made the long journey home with a much worse goal difference to show for the afternoon.
Ian Pearce was dismissed for Fulham after a desperate lunge which also gifted Reading an early penalty at Craven Cottage. Kevin Doyle calmly dispatched his seventh goal of the season from the spot. Collins-John wasted a great opportunity from eight yards to level the score and Reading held on for the win.
In Saturday's early kick-off Andy Reid scored his first goal for Charlton against Everton to cancel out an earlier Hermann Hreidarsson own goal in Les Reed's home debut. The point was still not enough to lift Charlton from the bottom of the table.
Luis Garcia wasted a great chance to open the scoring for Liverpool against Manchester City in the first-half at Anfield. Corradi went close for the visitors before a trademark Steven Gerrard pile-driver broke City's resolve and gave Liverpool all three points.
Malcolm Christie scored the game's opener for Middlesborough at Villa Park but Gareth Barry levelled with a penalty on the stroke of half-time. Villa had the bulk of the play in the second half but Martin O'Neill's men had to settle for yet another draw.
Hayden Mullins got on the end of a corner on to give West Ham the lead against Sheffield United in front of new owner Eggert Magnusson at Upton Park. Jonathan Spector had to scamper back to make a goal-line clearance as United fought back but they were unable to produce an equaliser.