PSV Eindhoven will be looking to consolidate their position at the top of the Eredivisie standings when they play host to Excelsior on Saturday.
Having unseated Ajax from the summit following their 10-man 1-0 victory at the Amsterdam ArenA last weekend, a slip up at home to an Excelsior side without a win in seven league and cup outings seems almost inconceivable.
No defeats and 19 goals scored in five league outings at home will mean that confidence is high going into the match at the Philips Stadion, while striker Jefferson Farfan will hope to continue the prolific form that has so far brought him eight goals in 10 league appearances.
Ajax, meanwhile, face something of a trickier task against FC Twente as they bid to bounce back from defeat.
Their failure to break down 10-man PSV will be of concern to coach Henk ten Cate, as will Twente's outrageous 7-1 demolition of FC Groningen last Sunday.
The defeat against PSV was Ajax's first at home since January, but the chances of a another slip up remain slim, with fourth-placed Twente inconsistent on the road so far this season, having won just once in five trips away from the Arke Stadion.
Third-placed AZ Alkmaar will be hopeful of continuing the form that has propelled them into the title reckoning when they visit Feyenoord on Saturday.
A 5-0 hammering of Heracles last weekend saw Fred Rutten's side close to within a point of Ajax in second, while maintaining the two-point gap to leaders PSV.
But a win against fifth-placed Feyenoord will not be easy to come by, with Erwin Koeman's men looking dangerous in front of goal during their 5-3 win against Willem II last weekend, although their obvious defensive frailties will give Rutten cause for optimism.
Elsewhere, Heracles get the weekend's action under way against NAC Breda on Friday night, NEC Nijmegen play host to struggling Sparta Rotterdam, and RKC Waalwijk welcome Heerenveen to the Mandemakers Stadion.
On Sunday, rock-bottom ADO Den Haag will be looking for only their second win of the campaign against Vitesse Arnhem, FC Groningen welcome Willem II to the Euroborg eager to get their season back on track after their mauling at the hands of Twente last time out, and Roda JC hit the road to face inconsistent FC Utrecht.