Real Madrid are again three points clear at the top of the Primera Division after a 3-0 win over Levante on Sunday.
Carlo Ancelotti's men watched on Saturday as Atletico won at Celta Vigo to return to level points with them, before responding with a three-goal win.
Cristiano Ronaldo got them going before the break, with Marcelo and an own goal from Nikos rounding things off after the break.
The win also means they are four points clear of defending champions Barcelona and surely have to be considered the favourite of the three sides chasing the title.
Athletic Bilbao and Valencia played out a thrilling 1-1 draw at the Mestalla, with both goals causing an equal amount of commotion.
Paco Alcacer looked to be in an offside position when he slid in to convert a cross from Sofiane Feghouli to put Valencia ahead, while Aritz Aduriz levelled after Athletic had been awarded a soft penalty, Ander Herrera colliding with Feghouli in the area.
A draw was not the result either team wanted, and it means Valencia slip five points behind seventh-placed Sevilla, while Athletic were unable to take full advantage of Villarreal's defeat at Granada, and could only extend their lead on Marcelino's side in the race for fourth place to seven points.
Elsewhere, Sevilla ensured their preparation for next week's Europa League derby clash with Real Betis was almost perfect with a 3-1 away win over Almeria.
Carlos Bacca, Daniel Carrico and Kevin Gameiro all scored for Sevilla with Aleix Vidal claiming a late consolation for the home side as the result kept the pressure on sixth-placed Real Sociedad, who are two points clear of Sevilla in the overall standings.
The scoreline also left struggling Almeria in the bottom three but only one point from safety in a congested bottom half of the table.
Espanyol gave their European hopes a further boost with a dominant 3-1 home win over Elche in the Primera Division.
The hosts needed just two minutes to open the scoring, David Lopez heading them in front from a corner. Diego Colotto got the second goal midway through the first half and Pizzi added a third in the second period, although Juan Rafael Fuentes scored an own goal to give the visitors a late consolation.
The victory means Espanyol can harbour serious ambitions about qualifying for Europe, now that they are just seven points behind sixth-placed Real Sociedad, while Elche are just three points above the bottom three.