Barcelona have confirmed Neymar will be sidelined for up to four weeks with the ankle injury he sustained on Thursday night.
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Neymar, 21, was substituted in the first half of Barcelona's 2-0 win at Getafe in the Copa del Rey after twisting his right ankle.
Barca have now revealed the extent of the injury, which has been diagnosed as a "peroneal tendon sprained right ankle."
A club statement read: "The approximate time out is three to four weeks. The Brazilian forward injured himself unluckily in the 22nd minute of the last 16 return Copa game against Getafe.
"This means Neymar will for sure miss the next three La Liga games against Levante, Malaga and Valencia, as well as the quarterfinals against Levante."
The Brazil international faces a race against time to be fit for Barcelona's Champions League last-16 first leg at Manchester City on Feb. 18.
The best-case scenario would see Neymar, whose summer transfer from Santos is still being looked into by court investigators in Madrid, return versus Sevilla at the beginning of February.