Chelsea booked their place in the fifth round of the Capital One Cup at Arsenal's expense as goals from Cesar Azpilicueta and Juan Mata clinched a 2-0 win at Emirates Stadium.
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Elsewhere, Javier Hernandez scored a brace to ensure Manchester United secured a comfortable 4-0 victory over Norwich City at Old Trafford, while Fulham lost 4-3 at Leicester and West Ham beat Burnley 2-0,
Jose Mourinho made ten changes to his Chelsea side for the trip to Arsenal but that did not hinder his team as they overcame the Premier League leaders 2-0.
Azpilicueta scored the opening goal of the game on 25 minutes as he pounced on a mistake from Carl Jenkinson, whose header back to Lukasz Fabianski was too weak.
Arsenal improved in the early stages of the second half and brought on Mesut Ozil in a bid to aid their chances of a comeback, but Mata's fine strike in the 66th minute wrapped up the win for the Blues.
Manchester United cruised to a 4-0 triumph against Norwich City with the help of two goals in each half from Mexico international Hernandez.
Chicharito's first goal came from the penalty spot as he duly tucked home after Adnan Januzaj was felled in the box by Leroy Fer.
And nine minutes into the second half Hernandez grabbed his second of the match after tucking home the rebound having seen his initial effort saved by Mark Bunn.
For Norwich, there was concern for midfielder Roberto Snodgrass after he went off on a stretcher following a clash of heads.
United's Phil Jones compounded their misery with a volley late on, before substitute Fabio rounded off a comprehensive success for the Red Devils.
Fulham's patchy league form carried over into the cup as they were knocked out by Leicester in a 4-3 thriller at the King Power Stadium.
Hugo Rodallega capitalised on some lax defending to give them an 18th-minute lead, but Leicester scored three in quick succession either side of half-time to turn it around -completely.
Wes Morgan levelled in the 41st minute on the rebound after Maarten Stekelenburg failed to hold Anthony Knockaert's free-kick, and Chris Wood put the Foxes ahead just before half-time when Philippe Senderos's clearance was blocked and the ball fell kindly.
Miguel Ignasi headed in a third early in the second half before Rodallega's almost instant response for Fulham set up a late rally, which looked complete when Giorgos Karagounis fired in an 86th-minute free-kick.
But no sooner were they level than Lloyd Dyer struck what would prove the winner.
West Ham edged out Sky Bet Championship leaders Burnley 2-0 at Turf Moor with both goals coming from the penalty spot late on.
Matthew Taylor got the first in the 76th minute after Jason Shackell brought down Kevin Nolan while Jack Collison tucked away the second in stoppage time after being fouled by Keith Treacy, who saw red to complete Burnley's misery.
Stoke needed penalties to see off the ten men of Birmingham at St Andrews after Blues scored twice in the last five minutes of the 90 to force extra time, and then equalised again in the 118th minute to make it 4-4.
Oussama Assaidi got the match off to a fine start with a 30-yard screamer in the 10th minute and although Tom Adeyemi levelled for Birmingham, they seemed doomed as Stoke took control after Wade Elliott was sent off on the stroke of
half-time as several players clashed.
Mark Hughes' side used the extra man to set up Crouch's 55th-minute header and Arnautovic's 71st-minute strike, with Crouch striking the crossbar with an overhead effort soon after.
That near miss allowed Peter Lovenkrands to tie it with goals in the 85th and 90th minutes, and although Kenwyne Jones put Stoke back in front four minutes into extra time, Olly Lee rifled home another late equaliser.
But Birmingham's brave effort fell short as Mitch Hancox and Callum Reilly missed their first two penalties, and Stoke won the shoot-out 4-2.