Frank Lampard has said Danny Welbeck's suspension for Tuesday's 2014 World Cup qualifier against Ukraine is a "big blow".
Welbeck scored twice for England in their 4-0 win over Moldova on Friday but picked up a booking that rules him out of the forthcoming trip to Kiev.
His absence leaves manager Roy Hodgson short of attacking options with Daniel Sturridge and Wayne Rooney injured, but Lampard is optimistic the Three Lions have enough depth.
The midfielder, who is set to earn his 100th England cap against Ukraine, said at a press conference: "It's a big blow, he's started the season well and he's a very talented player.
"I've enjoyed watching him for Man United and he scored two goals the other night but we've got players who can come in and do the same job.
"With Theo Walcott, Raheem Sterling, Ashley Young and James Milner, we've got a lot of depth on the wings."
England lead the group on goal difference from Montenegro, with Ukraine only a point behind and Poland also within striking distance.
And Lampard said: "We were very aware it was a tough group from the outset. People can dismiss a group when they don't see a Spain or a Germany but we were aware there were some tough teams there.
"We've got to go out on Tuesday and get a result. It's in our own hands with two home games to come after that.
"A win would put us in a very strong position. We've got two tough home games to come, but I think if we can fly back with three points then we're in a very strong position to go through."
Information from the Press Association was used in this report.