The Football Association has announced that Daniel Sturridge will not recover from his injury in time for England's World Cup qualifier against Ukraine.
Sturridge was sent back to his club Liverpool ahead of Friday's win over Moldova in the hope that he would return to fitness for next week's trip to Ukraine.
But the striker has failed to overcome his thigh problem, meaning England manager Roy Hodgon's attacking options are slim.
England cruised to a 4-0 scalp of Moldova at Wembley, but the match came at a cost as two-goal hero Danny Welbeck picked up a yellow card that rules him out of the Ukraine match.
Manchester United's Wayne Rooney is already absent due to a cut suffered to his head while West Ham's Andy Carroll is also unavailable.
Hodgson is left with Rickie Lambert, who scored against Moldova, and Jermain Defoe for Tuesday's crunch fixture in Kiev, with England looking to tighten their grip at the top of Group H.